Why Micronization Matters in Respiratory Medicine

In respiratory drug development, precision is everything. At Inke, we’ve spent over 25 years mastering one of the most technically demanding processes in pharmaceutical manufacturing: micronization.

But what exactly is micronization—and why is it so critical for inhaled therapies?

Understanding Micronization

A micron is one-millionth of a meter. In pharmaceutical terms, micronization refers to the process of reducing particle size to the low micron range—typically between 1 and 5 microns. This level of precision is essential for inhalation APIs, where the therapeutic effect depends on the drug reaching very specific regions of the respiratory tract.

The Science of Targeted Delivery

Inhaled therapies are designed to deliver medication directly to the lungs, minimizing systemic exposure and maximizing local efficacy. However, this only works if the particle size is just right:

• Too large, and particles are trapped in the upper airways, never reaching the lungs.
• Too small, and they may bypass the bronchial region entirely, reaching the alveoli and entering systemic circulation—potentially causing unwanted side effects.

At Inke, our inhalation APIs are engineered for optimal bronchial deposition, ensuring that the active ingredient reaches the intended site of action with maximum precision and therapeutic benefit.

A Legacy of Expertise

Micronization is not just a manufacturing step—it’s a science. It requires:

• Advanced particle engineering
• Rigorous analytical testing
• Deep understanding of regulatory requirements

Inke has built its reputation as a trusted partner to leading pharmaceutical companies worldwide by combining all three. Our specialized facilities and expert teams ensure that every batch of micronized API meets the highest standards of quality, consistency, and performance.

Precision Is Not a Luxury—It’s a Necessity

In the world of inhalation APIs, precision isn’t optional. It’s the foundation of effective respiratory medicine. That’s why Inke continues to invest in cutting-edge micronization technologies and analytical capabilities—so our partners can deliver safe, effective, and targeted therapies to patients around the globe.